Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinocarbinolaminas antimaláricas: proposta de um farmacóforo Molecular modeling study of complexes between ferriprotoporphyrin IX and antimalarial 4-quinolinecarbinolamines: a proposal of pharmacophore

Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinocarbinolaminas antimaláricas: proposta de um farmacóforo Molecular modeling study of complexes between ferriprotoporphyrin IX and antimalarial 4-quinolinecarbinolamines: a proposal of pharmacophore

<abstract language="eng">Quinine and quinidine are well-known 4-quinolinecarbinolamines that exhibit antimalarial activity, but, in contrast, their epimers 9-epiquinine and 9-epiquinidine are almost inactive. Literature data are conflicting in describing the 4-quinolinecarbinolamine...

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Bibliographic Details
Main Authors: Thais Horta Álvares da Silva, Marcelo Tavares de Oliveira, Hélio Ferreira dos Santos, Alaíde Braga de Oliveira, Wagner Batista De Almeida
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2005-03-01
Series:Química Nova
Subjects:
antimalarial
quinine
pharmacophore
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000200015

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