In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles

In situ triggering antitumor efficacy of alcohol-abuse drug disulfiram through Cu-based metal-organic framework nanoparticles

Although approved as an alcohol-abuse drug, disulfiram (DSF) exhibited potential anticancer activity when chelated with copper (Cu). However, the low level of intrinsic Cu, toxicity originated from exogenous Cu supplementation, and poor stability of DSF in vivo severely limited its application in ca...

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Bibliographic Details
Main Authors: Lin Hou, Yanlong Liu, Wei Liu, Mervat Balash, Hongling Zhang, Yi Zhang, Huijuan Zhang, Zhenzhong Zhang
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Disulfiram
Copper
Metal-organic framework
Hyaluronic acid
Lysosomal escape
DSF/Cu complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521000174

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