Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum

Antitumor Effects and Related Mechanisms of Penicitrinine A, a Novel Alkaloid with a Unique Spiro Skeleton from the Marine Fungus Penicillium citrinum

Penicitrinine A, a novel alkaloid with a unique spiro skeleton, was isolated from a marine-derived fungus Penicillium citrinum. In this study, the isolation, structure and biosynthetic pathway elucidation of the new compound were described. This new compound showed anti-proliferative activity on mu...

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Bibliographic Details
Main Authors: Qin-Ying Liu, Tong Zhou, Yang-Yang Zhao, Li Chen, Mei-Wei Gong, Qi-Wen Xia, Min-Gang Ying, Qiu-Hong Zheng, Qi-Qing Zhang
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Marine Drugs
Subjects:
penicitrinine A
marine-derived fungus
human malignant melanoma cell A-375
anticancer activity
apoptosis
anti-metastatic
Online Access:http://www.mdpi.com/1660-3397/13/8/4733

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