Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A

Abstract Background Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enzyme’s active site. Recent structural analysis of CypA in complex with C...

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Bibliographic Details
Main Authors: Wang Peng, Jiong Shi, Chantal L. Márquez, Derrick Lau, James Walsh, K. M. Rifat Faysal, Chang H. Byeon, In-Ja L. Byeon, Christopher Aiken, Till Böcking
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Retrovirology
Subjects:
HIV-1
Capsid
Cyclophilin A
Non-canonical binding site
Online Access:http://link.springer.com/article/10.1186/s12977-019-0471-4

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