Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group—A Model for yet Unknown Peptidases?

Fast Amide Bond Cleavage Assisted by a Secondary Amino and a Carboxyl Group—A Model for yet Unknown Peptidases?

Unconstrained amides that undergo fast hydrolysis under mild conditions are valuable sources of information about how amide bonds may be activated in enzymatic transformations. We report a compound possessing an unconstrained amide bond surrounded by an amino and a carboxyl group, each mounted in cl...

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Bibliographic Details
Main Authors: Igor V. Komarov, Aleksandr Yu. Ishchenko, Aleksandr Hovtvianitsa, Viacheslav Stepanenko, Serhii Kharchenko, Andrew D. Bond, Anthony J. Kirby
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
amide hydrolysis
model compound
intramolecular catalysis
twisted amide
protease
intein
Online Access:https://www.mdpi.com/1420-3049/24/3/572

Internet

https://www.mdpi.com/1420-3049/24/3/572

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