The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

The RNA-binding proteins PTBP1 and PTBP2 control programs of alternative splicing during neuronal development. PTBP2 was found to maintain embryonic splicing patterns of many synaptic and cytoskeletal proteins during differentiation of neuronal progenitor cells (NPCs) into early neurons. However, th...

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Bibliographic Details
Main Authors: Anthony J Linares, Chia-Ho Lin, Andrey Damianov, Katrina L Adams, Bennett G Novitch, Douglas L Black
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
alternative splicing
RNA binding protein
embryonic stem cells
posttranscriptional regulation
Online Access:https://elifesciences.org/articles/09268

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