Taurine effects on 24-hour blood pressure monitoring parameters in patients with chronic heart failure and metabolic syndrome

• Main Authors: I. V. Kryuchkova, A. S. Adamchik
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 1970-01-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: metabolic syndrome; chronic heart failure; 24-hour blood pressure monitoring; taurine
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/2164

Aim. To assess the effects of taurine on the parameters of 24-hour blood pressure monitoring (BPM) in patients with metabolic syndrome (MS) and chronic heart failure (CHF). Material and methods. In total, 60 patients were examined (mean age 54,4±7,4 years). The control group (CG) received enalapril and indapamide. The main group (MG) was additionally administered taurine for 12 months. All participants underwent anthropometry, office BP measurement, 24-hour BPM, and lipid profile assessment at baseline and at the end of the study. Results. The treatment was associated with changes in circadian profiles of systolic and diastolic BP (SBP, DBP) in both groups, with greater positive dynamics in the MG. The number of the patients with а “dipper” BP curve increased. Mean BP levels were significantly reduced. In the MG, time index for mean 24-hour SBP and DBP significantly decreased, by 49,9% and 42,3%, respectively. Mean 24-hour, day-time and night-time variability of SBP and DBP was normalised in the MG. Conclusion. Adding a metabolic agent to the combined antihypertensive therapy facilitated effective correction of circadian BP disturbances.