Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility

Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibility

Abstract Background Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not sufficient for development of MS. The...

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Bibliographic Details
Main Authors: Ali Afrasiabi, Grant P. Parnell, Nicole Fewings, Stephen D. Schibeci, Monica A. Basuki, Ramya Chandramohan, Yuan Zhou, Bruce Taylor, David A. Brown, Sanjay Swaminathan, Fiona C. McKay, Graeme J. Stewart, David R. Booth
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Genome Medicine
Subjects:
Multiple sclerosis
Genetics
Epstein-Barr virus
Risk genes
Expression quantitative trait loci
miRNA
Online Access:http://link.springer.com/article/10.1186/s13073-019-0640-z

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