H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1

Show other versions (1)

The H3K4me3 demethylase Kdm5a regulates gene transcription and is implicated in carcinogenesis. However, the role of Kdm5a in innate immune response remains poorly understood. Here, we demonstrate that Kdm5a deficiency impairs activation of natural killer (NK) cells, with decreased IFN-γ production....

Full description

Bibliographic Details
Main Authors:	Dezhi Zhao, Qian Zhang, Yiqi Liu, Xia Li, Kai Zhao, Yuanyuan Ding, Zhiqing Li, Qicong Shen, Chunmei Wang, Nan Li, Xuetao Cao
Format:	Article
Language:	English
Published:	Elsevier 2016-04-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124716302911

Similar Items

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1
by: Dezhi Zhao, et al.
Published: (2020-02-01)

<it>Drosophila </it>KDM2 is a H3K4me3 demethylase regulating nucleolar organization
by: Birchler James A, et al.
Published: (2009-10-01)

The role of the lysine demethylases KDM5 and KDM6 in bone malignancies
by: Hookway, Edward
Published: (2016)

Advances in Histone Demethylase KDM3A as a Cancer Therapeutic Target
by: Jung Yoo, et al.
Published: (2020-04-01)

Histone demethylase Kdm3a modulates bone formation in glucocorticoid-induced osteoporosis
by: Makoto Arai, et al.
Published: (2021-04-01)

Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11
by: Yishu Wang, et al.
Published: (2020-04-01)

Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor
by: Daohu Peng, et al.
Published: (2021-01-01)

KDM5 histone demethylases repress immune response via suppression of STING.
by: Lizhen Wu, et al.
Published: (2018-08-01)

Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3.
by: Maureen M Sherry-Lynes, et al.
Published: (2017-01-01)

KDM8, an H3K36me2 Histone Demethylase, Regulates Normoxia and Hypoxia Mediated Breast Cancer Cell Proliferation
by: Lin, Chun-Pu, et al.
Published: (2013)

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis
by: Qing-Jun Zhang, et al.
Published: (2018-12-01)

The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
by: Dominic Jones, et al.
Published: (2019-08-01)

The nuclear bodies formed by histone demethylase KDM7A
by: Hui Ming, et al.
Published: (2020-09-01)

Role of the histone demethylase KDM6A in pancreatic cancer
by: Lampraki, Eirini-Maria
Published: (2018)

Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC
by: Yongyue Wei, et al.
Published: (2018-04-01)

HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels.
by: Chia-Hui Lin, et al.
Published: (2012-01-01)

KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression
by: Xiang Yuan, et al.
Published: (2016-10-01)

Histone Demethylase KDM3A Promotes Cervical Cancer Malignancy Through the ETS1/KIF14/Hedgehog Axis
by: Liu J, et al.
Published: (2020-11-01)

The role of the KDM4 family histone 3 lysine 9 demethylases in hypertrophic remodelling of cardiac myocytes
by: Tingare, Asmita
Published: (2014)

Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer
by: Joyce Sayegh, et al.
Published: (2011-03-01)

Functional analysis of the KDM5B demethylase : in vitro and in vivo studies
by: Catchpole, Steven
Published: (2014)

Alternative isoforms of KDM2A and KDM2B lysine demethylases negatively regulate canonical Wnt signaling.
by: Dijana Lađinović, et al.
Published: (2020-01-01)

Histone Lysine Demethylases KDM5B and KDM5C Modulate Genome Activation and Stability in Porcine Embryos
by: Werner Giehl Glanzner, et al.
Published: (2020-03-01)

Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells
by: Liangtang Wu, et al.
Published: (2015-07-01)

Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells
by: Massimo Romani, et al.
Published: (2019-06-01)

KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance
by: Solenne Gaillard, et al.
Published: (2021-05-01)

Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells
by: Qi-Meng Li, et al.
Published: (2020-01-01)

Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C
by: Grafodatskaya Daria, et al.
Published: (2013-01-01)

Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock.
by: Mo-bin Cheng, et al.
Published: (2014-12-01)

Crystal Structure and Inhibitor Kinetics of Human Histone Demethylase Lysine-specific Demethylase 4B (KDM4B)
by: 陳仲勤
Published: (2013)

Funktion der Histon-Demethylase Kdm6a während der Teratombildung
by: Serfling, Sebastian
Published: (2015)

Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy
by: Anmi Jose, et al.
Published: (2020-07-01)

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
by: Marie Balslev Backe, et al.
Published: (2019-01-01)

Targeting Histone Demethylase LSD1/KDM1a in Neurodegenerative Diseases
by: Susanna Ambrosio, et al.
Published: (2018-03-01)

Depletion of Demethylase KDM6 Enhances Early Neuroectoderm Commitment of Human PSCs
by: Yajing Meng, et al.
Published: (2021-09-01)

The role of the histone demethylase KDM5B, in the normal and malignant mammary gland
by: Okonjo, Fiona Akinyi
Published: (2018)

Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.
by: Hyeonsoo Jung, et al.
Published: (2020-01-01)

Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase
by: Su-Hyun Lee, et al.
Published: (2021-02-01)

KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development.
by: Karl B Shpargel, et al.
Published: (2014-08-01)

Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A
by: Zoë S. Walters, et al.
Published: (2021-04-01)