Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability. A reduction in neuronal inhibition mediated by γ-aminobutyric acid type A receptors (GABAARs) has been implicated in the pathophysiology of FXS. Neuroactive steroids (NASs) are known allosteric modulators of GABAA...

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Bibliographic Details
Main Authors: Amit Modgil, Thuy N. Vien, Michael A. Ackley, James J. Doherty, Stephen J. Moss, Paul A. Davies
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
GABAA receptor (GABAAR)
tonic inhibition
neurosteroid
fragile X
phosphorylation
benzodiazepine
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00015/full

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