Inhibition of Phytosterol Biosynthesis by Azasterols
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of <i>Arabidopsis thaliana</i> sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a pl...
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MDPI AG
2020-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/5/1111 |
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doaj-6db61750ea2a42ec8c64390fb9e660202020-11-25T02:28:13ZengMDPI AGMolecules1420-30492020-03-01255111110.3390/molecules25051111molecules25051111Inhibition of Phytosterol Biosynthesis by AzasterolsSylvain Darnet0Laetitia B B Martin1Pierre Mercier2Franz Bracher3Philippe Geoffroy4Hubert Schaller5CVACBA, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-750, BrazilPlant Isoprenoid Biology (PIB) team, Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, 67084 Strasbourg, FrancePlant Isoprenoid Biology (PIB) team, Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, 67084 Strasbourg, FranceDepartment of Pharmacy, Center for Drug Research, Ludwig-Maximilians University Munich, 81377 Munich, GermanyInstitut de Chimie, Université de Strasbourg, 67008 Strasbourg, FrancePlant Isoprenoid Biology (PIB) team, Institut de Biologie Moléculaire des Plantes du CNRS, Université de Strasbourg, 67084 Strasbourg, FranceInhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of <i>Arabidopsis thaliana</i> sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development.https://www.mdpi.com/1420-3049/25/5/1111cholesterolsitosterolfungicideselective herbicidesbisteroidogenesis inhibitor |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sylvain Darnet Laetitia B B Martin Pierre Mercier Franz Bracher Philippe Geoffroy Hubert Schaller |
| spellingShingle |
Sylvain Darnet Laetitia B B Martin Pierre Mercier Franz Bracher Philippe Geoffroy Hubert Schaller Inhibition of Phytosterol Biosynthesis by Azasterols Molecules cholesterol sitosterol fungicide selective herbicide sbi steroidogenesis inhibitor |
| author_facet |
Sylvain Darnet Laetitia B B Martin Pierre Mercier Franz Bracher Philippe Geoffroy Hubert Schaller |
| author_sort |
Sylvain Darnet |
| title |
Inhibition of Phytosterol Biosynthesis by Azasterols |
| title_short |
Inhibition of Phytosterol Biosynthesis by Azasterols |
| title_full |
Inhibition of Phytosterol Biosynthesis by Azasterols |
| title_fullStr |
Inhibition of Phytosterol Biosynthesis by Azasterols |
| title_full_unstemmed |
Inhibition of Phytosterol Biosynthesis by Azasterols |
| title_sort |
inhibition of phytosterol biosynthesis by azasterols |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2020-03-01 |
| description |
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of <i>Arabidopsis thaliana</i> sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway. Side chain azasteroids that modify sitosterol homeostasis help to refine its particular function in plant development. |
| topic |
cholesterol sitosterol fungicide selective herbicide sbi steroidogenesis inhibitor |
| url |
https://www.mdpi.com/1420-3049/25/5/1111 |
| work_keys_str_mv |
AT sylvaindarnet inhibitionofphytosterolbiosynthesisbyazasterols AT laetitiabbmartin inhibitionofphytosterolbiosynthesisbyazasterols AT pierremercier inhibitionofphytosterolbiosynthesisbyazasterols AT franzbracher inhibitionofphytosterolbiosynthesisbyazasterols AT philippegeoffroy inhibitionofphytosterolbiosynthesisbyazasterols AT hubertschaller inhibitionofphytosterolbiosynthesisbyazasterols |
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