Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.

Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.

<h4>Background</h4>Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for...

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Bibliographic Details
Main Authors: Alvaro Cobo-Calvo, Anne Ruiz, Chloé Richard, Sandrine Blondel, Sylvie Cavagna, Nathalie Strazielle, Jean-François Ghersi-Egea, Pascale Giraudon, Romain Marignier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0238301

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