Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation

Pre-complexation of talin and vinculin without tension is required for efficient nascent adhesion maturation

Talin and vinculin are mechanosensitive proteins that are recruited early to integrin-based nascent adhesions (NAs). In two epithelial cell systems with well-delineated NA formation, we find these molecules concurrently recruited to the subclass of NAs maturing to focal adhesions. After the initial...

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Bibliographic Details
Main Authors: Sangyoon J Han, Evgenia V Azarova, Austin J Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R Horwitz, Benjamin T Goult, Kevin M Dean, Gaudenz Danuser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
epithelial cells
cell adhesion
talin
vinculin
integrin
traction force microscopy
Online Access:https://elifesciences.org/articles/66151

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