Rigid Scaffolds: Synthesis of 2,6‐Bridged Piperazines with Functional Groups in all three Bridges
Abstract The activity of pharmacologically active compounds can be increased by presenting a drug in a defined conformation, which fits exactly into the binding pocket of its target. Herein, the piperazine scaffold was conformationally restricted by substituted C2‐ or C3‐bridges across the 2‐ and 6‐...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley-VCH
2020-08-01
|
Series: | ChemistryOpen |
Subjects: | |
Online Access: | https://doi.org/10.1002/open.202000188 |