Rigid Scaffolds: Synthesis of 2,6‐Bridged Piperazines with Functional Groups in all three Bridges

Abstract The activity of pharmacologically active compounds can be increased by presenting a drug in a defined conformation, which fits exactly into the binding pocket of its target. Herein, the piperazine scaffold was conformationally restricted by substituted C2‐ or C3‐bridges across the 2‐ and 6‐...

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Bibliographic Details
Main Authors: Donglin Gao, Dr. Christian Penno, Prof. Bernhard Wünsch
Format: Article
Language:English
Published: Wiley-VCH 2020-08-01
Series:ChemistryOpen
Subjects:
Online Access:https://doi.org/10.1002/open.202000188