Downregulation of CD40L–CD40 attenuates seizure susceptibility and severity of seizures

Downregulation of CD40L–CD40 attenuates seizure susceptibility and severity of seizures

Abstract Unregulated neuro-inflammation mediates seizures in temporal lobe epilepsy (TLE). Our aim was to determine the effect of CD40–CD40L activation in experimental seizures. CD40 deficient mice (CD40KO) and control mice (wild type, WT) received pentenyltetrazole (PTZ) or pilocarpine to evaluate...

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Bibliographic Details
Main Authors: Esther Pototskiy, Katherine Vinokuroff, Andrew Ojeda, C. Kendall Major, Deepak Sharma, Taylor Anderson, Kendall Howard, Alberto E. Musto
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96760-3

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