Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer

“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”

Bibliographic Details
Main Authors:	Yunjiao Zhang, Rui Sha, Lan Zhang, Wenbin Zhang, Peipei Jin, Weiguo Xu, Jianxun Ding, Jun Lin, Jing Qian, Guangyu Yao, Rui Zhang, Fanchen Luo, Jie Zeng, Jie Cao, Long-ping Wen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-06529-y

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spelling	doaj-6d9863f38f444e3b807155513160f3b22021-05-11T09:22:32ZengNature Publishing GroupNature Communications2041-17232018-10-019111310.1038/s41467-018-06529-yHarnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancerYunjiao Zhang0Rui Sha1Lan Zhang2Wenbin Zhang3Peipei Jin4Weiguo Xu5Jianxun Ding6Jun Lin7Jing Qian8Guangyu Yao9Rui Zhang10Fanchen Luo11Jie Zeng12Jie Cao13Long-ping Wen14Department of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologySchool of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale, Center of Advanced Nanocatalysis (CAN-USTC) and Department of Chemical Physics, University of Science and Technology of ChinaDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyKey Laboratory of Polymer Ecomaterials, Changchun Institure of Applied Chemistry, Chinese Academy of SciencesKey Laboratory of Polymer Ecomaterials, Changchun Institure of Applied Chemistry, Chinese Academy of SciencesSchool of Life Sciences, University of Science and Technology of ChinaDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologySchool of Life Sciences, University of Science and Technology of ChinaDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologySchool of Life Sciences, University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at the Microscale, Center of Advanced Nanocatalysis (CAN-USTC) and Department of Chemical Physics, University of Science and Technology of ChinaDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of TechnologyDepartment of Colorectal & Anal Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”https://doi.org/10.1038/s41467-018-06529-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yunjiao Zhang Rui Sha Lan Zhang Wenbin Zhang Peipei Jin Weiguo Xu Jianxun Ding Jun Lin Jing Qian Guangyu Yao Rui Zhang Fanchen Luo Jie Zeng Jie Cao Long-ping Wen
spellingShingle	Yunjiao Zhang Rui Sha Lan Zhang Wenbin Zhang Peipei Jin Weiguo Xu Jianxun Ding Jun Lin Jing Qian Guangyu Yao Rui Zhang Fanchen Luo Jie Zeng Jie Cao Long-ping Wen Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer Nature Communications
author_facet	Yunjiao Zhang Rui Sha Lan Zhang Wenbin Zhang Peipei Jin Weiguo Xu Jianxun Ding Jun Lin Jing Qian Guangyu Yao Rui Zhang Fanchen Luo Jie Zeng Jie Cao Long-ping Wen
author_sort	Yunjiao Zhang
title	Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
title_short	Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
title_full	Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
title_fullStr	Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
title_full_unstemmed	Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
title_sort	harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-10-01
description	“Conventional chemotherapy-photothermal therapy combination has limited efficacy in drug resistant cancers. Here they develop Copper-palladium tetrapod nanoparticles to overcome these challenges and show them to work in synergy with autophagy inhibitors to treat drug resistant cancers”
url	https://doi.org/10.1038/s41467-018-06529-y
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Harnessing copper-palladium alloy tetrapod nanoparticle-induced pro-survival autophagy for optimized photothermal therapy of drug-resistant cancer

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