Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation

Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.

Bibliographic Details
Main Authors: Violet R. Mukaro, Alex Quach, Michelle E. Gahan, Bernadette Boog, Zhi H. Huang, Xiuhui Gao, Carol Haddad, Suresh Mahalingam, Charles S. Hii, Antonio Ferrante
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03640-y
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spelling doaj-6d8d32e467ee4dd0a9417a3616257e882021-05-11T09:43:22ZengNature Publishing GroupNature Communications2041-17232018-04-019111310.1038/s41467-018-03640-ySmall tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammationViolet R. Mukaro0Alex Quach1Michelle E. Gahan2Bernadette Boog3Zhi H. Huang4Xiuhui Gao5Carol Haddad6Suresh Mahalingam7Charles S. Hii8Antonio Ferrante9Department of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalFaculty of Science and Technology, University of CanberraDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalEmerging Viruses and Inflammation Research Group, Institute of Glycomics, Griffith UniversityDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalDepartment of Immunopathology, SA Pathology, Women’s and Children’s HospitalAnti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.https://doi.org/10.1038/s41467-018-03640-y
collection DOAJ
language English
format Article
sources DOAJ
author Violet R. Mukaro
Alex Quach
Michelle E. Gahan
Bernadette Boog
Zhi H. Huang
Xiuhui Gao
Carol Haddad
Suresh Mahalingam
Charles S. Hii
Antonio Ferrante
spellingShingle Violet R. Mukaro
Alex Quach
Michelle E. Gahan
Bernadette Boog
Zhi H. Huang
Xiuhui Gao
Carol Haddad
Suresh Mahalingam
Charles S. Hii
Antonio Ferrante
Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
Nature Communications
author_facet Violet R. Mukaro
Alex Quach
Michelle E. Gahan
Bernadette Boog
Zhi H. Huang
Xiuhui Gao
Carol Haddad
Suresh Mahalingam
Charles S. Hii
Antonio Ferrante
author_sort Violet R. Mukaro
title Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_short Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_full Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_fullStr Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_full_unstemmed Small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
title_sort small tumor necrosis factor receptor biologics inhibit the tumor necrosis factor-p38 signalling axis and inflammation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-04-01
description Anti-TNF therapy has improved the treatment of inflammatory disease but can predispose to infection and malignancy. Here the authors show an anti-TNF biologic peptide that functionally and selectively targets the TNF-p38 pathway in multiple models of inflammation.
url https://doi.org/10.1038/s41467-018-03640-y
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