Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway

Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway

Application of silica nanoparticles (SiO2-NPs) may result in human exposure. Here we investigate unexplored modes of action by which SiO2-NPs with average size of 225 nm act on human hepatoma cells (Huh7). We focused on the endoplasmic (ER) stress response and on mitogen-activated protein kinase (MA...

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Bibliographic Details
Main Authors: Verena Christen, Magdalena Camenzind, Karl Fent
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Tumor necrosis factor alpha
Human hepatoma cells
Proinflammatory response ;Iinterferon-stimulated genes
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014001206

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