BILE LITHOGENICITY IN PATIENTS WITH TYPE 2 DIABETES AND ITS CORRECTION
We conducted a study to assess the bile lithogenicity in patients with type 2 diabetes mellitus (DM). We have found increased levels of cholesterol both in the gallbladder and hepatic bile. The study showed a decrease of cholatocholesterol coefficient (HHC), increase of lithogenic index Thomas–Hofma...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-04-01
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| Series: | Bûlleten' Sibirskoj Mediciny |
| Subjects: | |
| Online Access: | https://bulletin.tomsk.ru/jour/article/view/34 |
| Summary: | We conducted a study to assess the bile lithogenicity in patients with type 2 diabetes mellitus (DM). We have found increased levels of cholesterol both in the gallbladder and hepatic bile. The study showed a decrease of cholatocholesterol coefficient (HHC), increase of lithogenic index Thomas–Hofmann and Rubens in all patients with type 2 diabetes, particularly in the gallbladder bile, indicating the colloidal destabilization of bile and an increased tendency to stone formation. Especially pronounced lithogenicity bile in patients with type 2 diabetes was associated with age in patients over 40 years of age and concomitant overweight or obese (BMI > 27 kg/m2). After a course of ursodeoxycholic acid (UDCA) at a dose of 15 mg/kg of body weight per day for 2.5–3 months was reduced lithogenicity gallbladder bile in patients with type 2 diabetes mellitus when the duration of disease was up to 5 years in 1.3 times, more than 5 years – in 1.5 times, more than 10 years – 1.7 times according to the index Thomas–Hofmann and Rubens. |
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| ISSN: | 1682-0363 1819-3684 |