Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis

Targeting Inflammatory T Helper Cells via Retinoic Acid-Related Orphan Receptor Gamma t Is Ineffective to Prevent Allo-Response-Driven Colitis

Intestinal graft-versus-host disease (GvHD) is a life-threatening, inflammatory donor T cell-mediated complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In the light of the reported efficacy of interleukin-23 (IL-23)-blockade to mitigate syngeneic intestinal inflammation...

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Bibliographic Details
Main Authors: Vera Buchele, Benjamin Abendroth, Maike Büttner-Herold, Tina Vogler, Johanna Rothamer, Sakhila Ghimire, Evelyn Ullrich, Ernst Holler, Markus F. Neurath, Kai Hildner
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
retinoic acid-related orphan receptor gamma t
interleukin-23 receptor
T helper 17 cells
granulocyte-macrophage colony-stimulating factor
basic leucine zipper transcription factor ATF-like
intestinal graft-versus-host disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01138/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01138/full

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