Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

Although melatonin is widely known for its nephroprotective properties, there are no reports clearly pointing at its impact on the activity of hypoxia-inducible factor-1 (HIF-1), the main mediator of metabolic responses to hypoxia, in kidneys. The aim of the present study was to elucidate how melato...

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Bibliographic Details
Main Authors: Aleksandra Owczarek, Katarzyna B. Gieczewska, Marta Polanska, Bohdan Paterczyk, Andrzej Gruza, Katarzyna Winiarska
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Physiology
Subjects:
melatonin
hypoxia-inducible factor-1
sirtuin 1
hypoxia
HK-2 cells
kidney
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.572911/full

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