Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolino...

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Main Authors:	Heba E. Hashem, Ahmed M. Abo-Bakr
Format:	Article
Language:	English
Published:	Hindawi-Wiley 2019-01-01
Series:	Heteroatom Chemistry
Online Access:	http://dx.doi.org/10.1155/2019/2326514

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spelling	doaj-6d74cf072d594c85897cf51afd1ebdeb2020-11-25T01:30:45ZengHindawi-WileyHeteroatom Chemistry1042-71631098-10712019-01-01201910.1155/2019/23265142326514Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial ActivityHeba E. Hashem0Ahmed M. Abo-Bakr1Department of Chemistry, Faculty of Women, Ain Shams University, Heliopolis, Cairo 11457, EgyptDepartment of Chemistry, Faculty of Science, South Valley University, 83523 Qena, Egypt1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolinone derivatives. 1,2,5-Oxadiazine has been used as a synthon for the fused pyrazolo-oxadiazine derivative. The constitution of the prepared compounds was built up based on microanalytical and spectral data. Some of the new compounds were assessed for their antimicrobial activity.http://dx.doi.org/10.1155/2019/2326514
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Heba E. Hashem Ahmed M. Abo-Bakr
spellingShingle	Heba E. Hashem Ahmed M. Abo-Bakr Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity Heteroatom Chemistry
author_facet	Heba E. Hashem Ahmed M. Abo-Bakr
author_sort	Heba E. Hashem
title	Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity
title_short	Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity
title_full	Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity
title_fullStr	Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity
title_full_unstemmed	Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity
title_sort	synthesis of some new 1,2,4-triazine and 1,2,5-oxadiazine derivatives with antimicrobial activity
publisher	Hindawi-Wiley
series	Heteroatom Chemistry
issn	1042-7163 1098-1071
publishDate	2019-01-01
description	1,2,4-Triazine and 1,2,5-oxadiazine derivatives 2–12 were obtained from treated 1,3-oxazolone (1) with phenyl hydrazine or hydroxylamine hydrochloride. Chlorotriazine derivative 3 undergoing condensation reactions with different reagents produced new fused tetrazolo-triazine and triazino-quinazolinone derivatives. 1,2,5-Oxadiazine has been used as a synthon for the fused pyrazolo-oxadiazine derivative. The constitution of the prepared compounds was built up based on microanalytical and spectral data. Some of the new compounds were assessed for their antimicrobial activity.
url	http://dx.doi.org/10.1155/2019/2326514
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Synthesis of Some New 1,2,4-Triazine and 1,2,5-Oxadiazine Derivatives with Antimicrobial Activity

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