Nephroprotective activity of Combretum micranthum G. Don in cisplatin induced nephrotoxicity in rats: In-vitro, in-vivo and in-silico experiments

Nephroprotective activity of Combretum micranthum G. Don in cisplatin induced nephrotoxicity in rats: In-vitro, in-vivo and in-silico experiments

Nephrotoxicity is known to be a major complication during cisplatin chemotherapy in cancer patients. In the present study, the protective effect of a hydroalcoholic extract of Combretum micranthum (CM) against cisplatin (CP)-induced renal damage was evaluated using in-vitro human embryonic kidney (H...

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Bibliographic Details
Main Authors: Mabozou Kpemissi, Kwashie Eklu-Gadegbeku, Veeresh P. Veerapur, Mihai Negru, Marian Taulescu, Vivek Chandramohan, Jagadheshan Hiriyan, Siddalingesh M. Banakar, Thimmaiah NV, Doddamavattur Shivalingaiah Suhas, Tumbadi Adinarayanashetty Puneeth, Sachidananda Vijayakumar, Kossi Metowogo, Kodjo Aklikokou
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Kidney
Nephrotoxicity
HEK-293
Oxidative stress
Molecular docking
Molecular dynamic studies
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219315124

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