A check valve controlled laser-induced microjet for uniform transdermal drug delivery

A check valve controlled laser-induced microjet for uniform transdermal drug delivery

A narrow nozzle ejects a microjet of 150 μm in diameter with a velocity of 140 m/s a by the laser-induced bubble expansion in the designed injector. The pulsed form of the driving force at a period of 10 Hz from the connected Er:YAG laser makes it possible for multiple microjet ejections aimed at de...

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Main Authors: Hwi-chan Ham, Hun-jae Jang, Jack J. Yoh
Format: Article
Language:English
Published: AIP Publishing LLC 2017-12-01
Series:AIP Advances
Online Access:http://dx.doi.org/10.1063/1.4999962
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spelling doaj-6d523fff051f428a82858bac251ea9d12020-11-24T21:09:09ZengAIP Publishing LLCAIP Advances2158-32262017-12-01712125206125206-1110.1063/1.4999962015712ADVA check valve controlled laser-induced microjet for uniform transdermal drug deliveryHwi-chan Ham0Hun-jae Jang1Jack J. Yoh2Department of Mechanical and Aerospace Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 151-742, KoreaDepartment of Mechanical and Aerospace Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 151-742, KoreaDepartment of Mechanical and Aerospace Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 151-742, KoreaA narrow nozzle ejects a microjet of 150 μm in diameter with a velocity of 140 m/s a by the laser-induced bubble expansion in the designed injector. The pulsed form of the driving force at a period of 10 Hz from the connected Er:YAG laser makes it possible for multiple microjet ejections aimed at delivery of drugs into a skin target. The pulsed actuation of the microjet generation is however susceptible to the air leak which can cause the outside air to enter into the momentarily de-pressurized nozzle, leading to a significant reduction of the microjet speed during the pulsed administering of the drug. In the present study, we designed a ball-check valve injector which is less prone to an unwanted air build up inside the nozzle by controlling the nozzle pressure to remain above ambient pressure at all times. The new device is rigorously compared against the reported performance of the previous injector and has shown to maintain about 97% of the initial microjet speed regardless of the number of shots administered; likewise, the drug penetration depth into a porcine skin is improved to 1.5 to 2.25 times the previously reported penetration depths.http://dx.doi.org/10.1063/1.4999962
collection DOAJ
language English
format Article
sources DOAJ
author Hwi-chan Ham
Hun-jae Jang
Jack J. Yoh
spellingShingle Hwi-chan Ham
Hun-jae Jang
Jack J. Yoh
A check valve controlled laser-induced microjet for uniform transdermal drug delivery
AIP Advances
author_facet Hwi-chan Ham
Hun-jae Jang
Jack J. Yoh
author_sort Hwi-chan Ham
title A check valve controlled laser-induced microjet for uniform transdermal drug delivery
title_short A check valve controlled laser-induced microjet for uniform transdermal drug delivery
title_full A check valve controlled laser-induced microjet for uniform transdermal drug delivery
title_fullStr A check valve controlled laser-induced microjet for uniform transdermal drug delivery
title_full_unstemmed A check valve controlled laser-induced microjet for uniform transdermal drug delivery
title_sort check valve controlled laser-induced microjet for uniform transdermal drug delivery
publisher AIP Publishing LLC
series AIP Advances
issn 2158-3226
publishDate 2017-12-01
description A narrow nozzle ejects a microjet of 150 μm in diameter with a velocity of 140 m/s a by the laser-induced bubble expansion in the designed injector. The pulsed form of the driving force at a period of 10 Hz from the connected Er:YAG laser makes it possible for multiple microjet ejections aimed at delivery of drugs into a skin target. The pulsed actuation of the microjet generation is however susceptible to the air leak which can cause the outside air to enter into the momentarily de-pressurized nozzle, leading to a significant reduction of the microjet speed during the pulsed administering of the drug. In the present study, we designed a ball-check valve injector which is less prone to an unwanted air build up inside the nozzle by controlling the nozzle pressure to remain above ambient pressure at all times. The new device is rigorously compared against the reported performance of the previous injector and has shown to maintain about 97% of the initial microjet speed regardless of the number of shots administered; likewise, the drug penetration depth into a porcine skin is improved to 1.5 to 2.25 times the previously reported penetration depths.
url http://dx.doi.org/10.1063/1.4999962
work_keys_str_mv AT hwichanham acheckvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
AT hunjaejang acheckvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
AT jackjyoh acheckvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
AT hwichanham checkvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
AT hunjaejang checkvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
AT jackjyoh checkvalvecontrolledlaserinducedmicrojetforuniformtransdermaldrugdelivery
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