TACTICS OF BIOCENOSIS-SAVING THERAPY BY USE ANTIBIOTICS IN CHILDREN WITH ACUTE INTESTINAL INFECTIONS

• Main Authors: L. N. Mazankova, A. A. Korsunsky, A. P. Prodeus, M. D. Ardatskaya, S. G. Perlovskaya
• Format: Article
• Language: Russian
• Published: LLC "Diagnostics and Vaccines" 2017-09-01
• Series: Detskie Infekcii (Moskva)
• Subjects: biocenosis-saving therapy; antibiotics; acute intestinal infections (aii); short-chain fatty acids (scfas); children; gelatin tannat
• Online Access: https://detinf.elpub.ru/jour/article/view/307

50 children aged from 3 to 67 months with acute intestinal infections receiving antibiotic therapy, were clinically and microbiologically examined using gas-liquid chromatographic test with the measurement of short-chain fatty acids (SCFAs) in coprofiltrates. The influence on the biocenosis is assessed upon treatment with an-tidiarrhoeal medication Gelatin tannat (Adiarin), which acts by forming a protective film on the surface of intestinal mucosa preventing loss of body fluids and microbial toxins. 20 children in the control group received antibiotics, sorbents, probiotics. The study has proved the clinical effect of Gelatin tannat, resulting in reduction of time to normalization of diarrhea and intoxication for 2 days, and data on the probiotic effect of the drug, similar to that of probiotics in the control group which expands the indications for the use of Gelatin tannat for prevention of antibiotic-associated diarrhea.