Statistical characteristics and correlations of histomorphometric, clinical and biochemical indices in systemic therapy in patients with osteogenesis imperfecta

• Main Authors: V. V. Hryhorovskyi, A. M. Zyma, Yu. M. Guk, S. Mahomedov, O. G. Gayko, T. A. Kintchaia-Polishchuk
• Format: Article
• Language: English
• Published: Zaporozhye State Medical University 2015-04-01
• Series: Patologìâ
• Subjects: Osteogenesis Imperfecta; Drug Therapy; Densitometry; Biochemistry; Pamidronate
• Online Access: http://pat.zsmu.edu.ua/article/view/42883/39284

Actuality. The correlation analysis between various indices of bone tissue condition was not previously carried out in patients with osteogenesis imperfecta. Aim. On purpose to determine differences and index correlations before and after intake of pamidronate systemic therapy in 13 patients with osteogenesis imperfecta indices of some methods including histomorphometric were studied. Results. We found correlation parametres of biochemical indices, on one side and histomorphometric – on the other. Conclusion. After systemic therapy mean parametres of «bone volume» in iliobiopsies increase, and «osteoid surface» and «osteoclast index per surface unit» in patients with osteogenesis imperfecta of I type – decrease, that one can regard as a tendency to improvement of the bone tissue structural-functional condition.