Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.

Bibliographic Details
Main Authors: Jinping Liu, Alex Kruswick, Hien Dang, Andy D. Tran, So Mee Kwon, Xin Wei Wang, Philipp Oberdoerffer
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00206-2
id doaj-6d416f5188234f9fa281c79b9c130b8a
record_format Article
spelling doaj-6d416f5188234f9fa281c79b9c130b8a2021-01-31T12:30:56ZengNature Publishing GroupNature Communications2041-17232017-07-018111210.1038/s41467-017-00206-2Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growthJinping Liu0Alex Kruswick1Hien Dang2Andy D. Tran3So Mee Kwon4Xin Wei Wang5Philipp Oberdoerffer6Laboratory of Receptor Biology and Gene Expression, National Cancer InstituteLaboratory of Receptor Biology and Gene Expression, National Cancer InstituteLaboratory of Human Carcinogenesis, National Cancer InstituteLaboratory of Receptor Biology and Gene Expression, National Cancer InstituteLaboratory of Human Carcinogenesis, National Cancer InstituteLaboratory of Human Carcinogenesis, National Cancer InstituteLaboratory of Receptor Biology and Gene Expression, National Cancer InstituteBRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.https://doi.org/10.1038/s41467-017-00206-2
collection DOAJ
language English
format Article
sources DOAJ
author Jinping Liu
Alex Kruswick
Hien Dang
Andy D. Tran
So Mee Kwon
Xin Wei Wang
Philipp Oberdoerffer
spellingShingle Jinping Liu
Alex Kruswick
Hien Dang
Andy D. Tran
So Mee Kwon
Xin Wei Wang
Philipp Oberdoerffer
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
Nature Communications
author_facet Jinping Liu
Alex Kruswick
Hien Dang
Andy D. Tran
So Mee Kwon
Xin Wei Wang
Philipp Oberdoerffer
author_sort Jinping Liu
title Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_short Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_full Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_fullStr Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_full_unstemmed Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth
title_sort ubiquitin-specific protease 21 stabilizes brca2 to control dna repair and tumor growth
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-07-01
description BRCA2 is essential for the repair of DNA damage; therefore, defects in BRCA2 are associated with tumorigenesis but also with increased susceptibility to genotoxic stress. Here the authors show that USP21 regulates the ability of tumor cells to repair damaged DNA by regulating BRCA2 stability.
url https://doi.org/10.1038/s41467-017-00206-2
work_keys_str_mv AT jinpingliu ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT alexkruswick ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT hiendang ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT andydtran ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT someekwon ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT xinweiwang ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
AT philippoberdoerffer ubiquitinspecificprotease21stabilizesbrca2tocontroldnarepairandtumorgrowth
_version_ 1724317205373386752

Similar Items