Screening diagnostics of large intestine diseases in children

• Main Authors: K.V. Voloshyn, N.V. Pavlenko, O.O. Rzhevska, O.V. Drachevska
• Format: Article
• Language: English
• Published: Publishing House Zaslavsky 2019-04-01
• Series: Zdorovʹe Rebenka
• Subjects: children; screening; intestine; calprotectin; lacto­ferrin
• Online Access: http://childshealth.zaslavsky.com.ua/article/view/165527
• ISSN: 2224-0551; 2307-1168

Background. Questions of the screening diagnostics of large intestine diseases in children at the prehospital and primary stages of medical care are relevant. Fecal markers of intestinal inflammation testing in children with complaints and clinical manifestations typical to the pathology of the large intestine are proposed as a non-invasive and economically accessible diagnostic method. The purpose of the study was a comparative analysis of the large intestine mucous membrane state with the results of the fecal markers of intestinal inflammation testing. Materials and me­thods. Forty children aged 6–18 years old were examined. The diagnosis was verified by endoscopy in all children. Fecal markers of intestinal inflammation were determined using Calprotectin-Lactoferrin CITO TEST. Results. Comparison of the results of endoscopic studies with that of fecal markers of intestinal inflammation test indicates a significant coincidence (95 %; p < 0.05) of positive results of Cito Test Calprotectin-Lactoferrin with signs of inflammation in the large intestine founded in endoscopy. Conclusions. It has been shown that the proposed method of screening diagnostics for the determination of fecal markers of intestinal inflammation is sufficiently sensitive and can be used at the prehospital and primary diagnostic stages, including the selection of a group of patients for subsequent endoscopic examination.