Characterization of a fusion protein of RGD4C and the ß-lactamase variant for antibody-directed enzyme prodrug therapy

Characterization of a fusion protein of RGD4C and the ß-lactamase variant for antibody-directed enzyme prodrug therapy

Xiaoliang Zhou, Hao Wang, Peiji Shi, Ai-min MengInstitute of Radiation Medicine, Tianjin Key Laboratory of Molecular Nuclear Medicine, Tianjin, People's Republic of ChinaAbstract: Antibody-directed enzyme prodrug therapy (ADEPT) delivers chemotherapeutic agents in high concentration to tumo...

Full description

Bibliographic Details
Main Authors:	Zhou XL, Wang H, Shi PJ, Meng AM
Format:	Article
Language:	English
Published:	Dove Medical Press 2014-04-01
Series:	OncoTargets and Therapy
Online Access:	http://www.dovepress.com/characterization-of-a-fusion-protein-of-rgd4c-and-the-szlig-lactamase--a16425

Similar Items

A Fusion Protein of RGD4C and β-Lactamase Has a Favorable Targeting Effect in Its Use in Antibody Directed Enzyme Prodrug Therapy
by: Hao Wang, et al.
Published: (2015-04-01)

Antibody directed enzyme prodrug therapy : a mechanistic approach
by: Francis, Roslyn Jane
Published: (2005)

Pharmacokinetic and pharmacodynamic challenges of Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
by: Andrady, C.
Published: (2014)

Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
by: William A. Denny
Published: (2003-01-01)

Optimized prodrug vehicles with targeting ability: the RGD4C-EcCD fusion proteins
by: Yung-Hsiang Weng, et al.
Published: (2018)

Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT)
by: Leu, Yu-Ling, et al.
Published: (1999)

PDEPT : polymer directed enzyme prodrug therapy
by: Satchi, Ronit
Published: (1999)

Carotenoporphyrin prodrugs for antibody directed photodynamic therapy
by: Radford, F.
Published: (2003)

Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy
by: Adam V. Patterson, et al.
Published: (2009-11-01)

LEAPT : lectin-directed enzyme activated prodrug therapy
by: Robinson, Mark Alexander
Published: (2003)

Potential of unglycosylated horseradish peroxidase variants for enzyme prodrug cancer therapy
by: Diana Humer, et al.
Published: (2021-10-01)

Activation of Methotrexate Prodrugs by Enzyme/Monoclonal Antibody Conjugates
by: Vitols K. S., et al.
Published: (1991-02-01)

Use of horseradish peroxidase for gene directed enzyme prodrug therapy
by: Tupper, Joanna
Published: (2004)

Treatment of cancer with prodrugs activated by antibody targeted enzyme conjugates
by: WANG, XING-MIN, et al.
Published: (1992)

Investigation of RGD-EGFP Fusion Proteins in RGD-Mediated Protein Internalization
by: Han Chiang, et al.
Published: (2001)

Bacterial directed enzyme prodrug therapy using carboxypeptidase G2
by: Lehouritis, Panos
Published: (2006)

Substrate mediated enzyme prodrug therapy.
by: Betina Fejerskov, et al.
Published: (2012-01-01)

Nitroreductases for use in Enzyme Prodrug Therapy
by: Emptage, Caroline Dawn
Published: (2007)

Idiopathic intracranial hypertension, hormones, and 11ß-hydroxysteroid dehydrogenases
by: Markey KA, et al.
Published: (2016-04-01)

Anti-tumor effect of antibody-enzyme conjugates in combination with glucuronide prodrugs
by: Zheng, Tian-Lu, et al.
Published: (1993)

A study of the pharmacology of different prodrugs in conjunction with target antibody-enzyme in human cancer therapy
by: Antoniw, Pari
Published: (1991)

The complex regulation of TGF-&szlig; in cardiovascular disease
by: Redondo S, et al.
Published: (2012-09-01)

Magnetically Directed Enzyme/Prodrug Prostate Cancer Therapy Based on β-Glucosidase/Amygdalin
by: Zhou J, et al.
Published: (2020-06-01)

Virus-directed enzyme prodrug therapy and the assessment of the cytotoxic impact of some benzimidazole derivatives
by: Michał Szewczuk, et al.
Published: (2017-07-01)

An investigation of enzyme/prodrug systems for cancer gene therapy
by: Denning, Chris N.
Published: (1997)

Novel prodrug-converting enzymes and a directed DNA integration method for clostridia
by: Heap, John Timothy
Published: (2007)

Enzyme-mediated hydrolytic activation of prodrugs
by: Yan-hui Yang, et al.
Published: (2011-10-01)

Enzyme Models—From Catalysis to Prodrugs
by: Zeinab Breijyeh, et al.
Published: (2021-05-01)

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy
by: David F. Ackerley, et al.
Published: (2013-08-01)

Gene-Directed Enzyme Prodrug Therapy by Dendrimer-Like Mesoporous Silica Nanoparticles against Tumor Cells
by: Vicente Candela-Noguera, et al.
Published: (2021-05-01)

Targeted enzyme activation of anti-neoplastic prodrugs for therapy of metastasis
by: Show Len Wei, et al.
Published: (1995)

Use of a direct, positive selection strategy to generate improved prodrug-activating enzymes for cancer gene therapy
by: Baker, Shelley Louise
Published: (2011)

Catalytic antibodies for amide cleavage and prodrug activation
by: Fleck, Roman (Roman W.), 1966-
Published: (2005)

Choosing the ‘ß' Parameter When Using the Bonacich Power Measure
by: Simon Rodan
Published: (2011-12-01)

Enhanced and selective delivery of enzyme therapy to 9L-glioma tumor via magnetic targeting of PEG-modified, ß-glucosidase- conjugated iron oxide nanoparticles
by: Zhou J, et al.
Published: (2014-06-01)

Gene-directed enzyme prodrug therapy with CPG2-ZD2767P : novel vaccina vectors and combination with radiotherapy
by: Ajaz, Mazhar
Published: (2010)

Polymeric Nanovectors Incorporated with Ganciclovir and HSV-<i>tk</i> Encoding Plasmid for Gene-Directed Enzyme Prodrug Therapy
by: Alicia J. Sawdon, et al.
Published: (2021-03-01)

Computational Simulations to Guide Enzyme-Mediated Prodrug Activation
by: Milica Markovic, et al.
Published: (2020-05-01)

Prodrug converting enzyme gene delivery by <it>L. monocytogenes</it>
by: Pilgrim Sabine, et al.
Published: (2008-04-01)

The design of a prodrug to utilise the thymidine phosphorylase enzyme
by: Campbell, Robert Malcolm
Published: (2003)