Evaluation of the effectiveness of the “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III

• Main Authors: Viktoriia Petrushenko, Dmytro Hrebeniuk, Oleh Skupyi, Kostiantyn Lonskyi, Vadym Stoika
• Format: Article
• Language: Russian
• Published: Interdisciplinary Academy of Pain Medicine 2020-06-01
• Series: Perioperative Medicine
• Subjects: occlusion disease of the peripheral arteries; chronic arterial insufficiency; Latren; Rheosorbilact; Tivortin; painless walking distance
• Online Access: https://perioperative.org.ua/index.php/prtmdc/article/view/37
• ISSN: 2616-339X; 2617-2925

Background. Despite constant progress in the study of the etiopathogenetic aspects of the disease, the development and implementation of new methods of treatment, the search for optimal pharmacotherapy regimens, the problem of occlusion disease of the peripheral arteries of the lower extremities continues to be extremely relevant. The aim of the study was to evaluate the effectiveness of the “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III. Materials and methods. According to the aims and objectives, 45 patients with a confirmed diagnosis of peripheral arterial occlusive disease of the lower extremities and chronic arterial insufficiency IIb-III were included in the study. All patients from the study population were randomly divided into two groups. Patients from experimental group received “TRIO” pharmacotherapy (Latren, Rheosorbilact, Tivortin). Patients from comparison group received medical therapy with Rheosorbilact and Tivortin. Results. The duration of hospital stay was significantly shorter (p < 0.01) in the experimental group (7.9 ± 0.97 days) than in the comparison group (9.8 ± 1.63 days). After treatment painless walking distance and peripheral oxygen saturation were significantly greater (p < 0.01) in the experimental group (126.25 ± 72.16 m and 90.65 ± 5.07 %, respectively) than in the comparison group (54.20 ± 33.59 m and 79.48 ± 6.91 %, respectively). At the same time, the intensity of pain was significantly lower (p < 0.01) in the experimental group (3.25 ± 1.68 points) than in the comparison group (4.80 ± 1.53 points). The values of the ankle-brachial pressure index were not differing (p < 0.05) in both groups (0.49 ± 0.16 and 0.51 ± 0.17 for the experimental group and comparison group, respectively). Conclusions. “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb–III allows to improve the basic indicators of the functional state of the microvasculature of the lower extremities.