Brain-Dependent Processes Fuel Pain-Induced Hemorrhage After Spinal Cord Injury

Brain-Dependent Processes Fuel Pain-Induced Hemorrhage After Spinal Cord Injury

Pain (nociceptive) input caudal to a spinal contusion injury can undermine long-term recovery and increase tissue loss (secondary injury). Prior work suggests that nociceptive stimulation has this effect because it fosters the breakdown of the blood-spinal cord barrier (BSCB) at the site of injury,...

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Bibliographic Details
Main Authors: Joshua A. Reynolds, Melissa K. Henwood, Joel D. Turtle, Rachel E. Baine, David T. Johnston, James W. Grau
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Systems Neuroscience
Subjects:
spinal cord injury
pain
hemorrhage
cytokines
caspase
nociception
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2019.00044/full

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