Structure-Based Virtual Screening and In Vitro Evaluation of New <i>Trypanosoma cruzi</i> Cruzain Inhibitors

Structure-Based Virtual Screening and In Vitro Evaluation of New <i>Trypanosoma cruzi</i> Cruzain Inhibitors

Chagas disease (CD), or American trypanosomiasis, causes more than 10,000 deaths per year in the Americas. Current medical therapy for CD has low efficacy in the chronic phase of the disease and serious adverse effects; therefore, it is necessary to search for new pharmacological treatments. In this...

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Main Authors: Verónica Herrera-Mayorga, Edgar E. Lara-Ramírez, Karla F. Chacón-Vargas, Charmina Aguirre-Alvarado, Lorena Rodríguez-Páez, Verónica Alcántara-Farfán, Joaquín Cordero-Martínez, Benjamín Nogueda-Torres, Francisco Reyes-Espinosa, Virgilio Bocanegra-García, Gildardo Rivera
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Trypanosoma cruzi</i>
molecular docking
cruzain
Zinc<sup>15</sup>
inhibitors
Online Access:https://www.mdpi.com/1422-0067/20/7/1742

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