The Dramatic Modulatory Role of the 2'N Substitution of the Terminal Amino Hexose of Globotetraosylceramide in Determining Binding by Members of the Verotoxin Family

The Dramatic Modulatory Role of the 2'N Substitution of the Terminal Amino Hexose of Globotetraosylceramide in Determining Binding by Members of the Verotoxin Family

Although globotetraosylceramide (Gb4) is only recognized by a single member of the verotoxin family namely, the pig edema disease toxin (VT2e), removal of the acetyl group from the terminal N-acetyl hexosamine of Gb4 to generate the free amino sugar containing species (aminoGb4) results in the gener...

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Bibliographic Details
Main Authors: Murugesapillai Mylvaganam, Beth Binnington, Monique Budani, Anna M. Soltyk, Clifford A. Lingwood
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Chromatography
Subjects:
shiga toxin receptor
globotetraosylceramide
amino substitution
Online Access:http://www.mdpi.com/2227-9075/2/3/529

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