Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.

Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypothesis that 808 nm infrared light that e...

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Main Authors: Melissa Vos, Blaise Lovisa, Ann Geens, Vanessa A Morais, Georges Wagnières, Hubert van den Bergh, Alec Ginggen, Bart De Strooper, Yanik Tardy, Patrik Verstreken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823844?pdf=render
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spelling doaj-6d0b93c3ff114760812c7c0d1c08a0022020-11-25T01:34:53ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7856210.1371/journal.pone.0078562Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.Melissa VosBlaise LovisaAnn GeensVanessa A MoraisGeorges WagnièresHubert van den BerghAlec GinggenBart De StrooperYanik TardyPatrik VerstrekenMitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypothesis that 808 nm infrared light that effectively penetrates tissues rescues pink1 mutants. We show that irradiating isolated fly or mouse mitochondria with 808 nm light that is absorbed by ETC-Complex IV acutely improves Complex IV-dependent oxygen consumption and ATP production, a feature that is wavelength-specific. Irradiating Drosophila pink1 mutants using a single dose of 808 nm light results in a rescue of major systemic and mitochondrial defects. Time-course experiments indicate mitochondrial membrane potential defects are rescued prior to mitochondrial morphological defects, also in dopaminergic neurons, suggesting mitochondrial functional defects precede mitochondrial swelling. Thus, our data indicate that improvement of mitochondrial function using infrared light stimulation is a viable strategy to alleviate pink1-related defects.http://europepmc.org/articles/PMC3823844?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Melissa Vos
Blaise Lovisa
Ann Geens
Vanessa A Morais
Georges Wagnières
Hubert van den Bergh
Alec Ginggen
Bart De Strooper
Yanik Tardy
Patrik Verstreken
spellingShingle Melissa Vos
Blaise Lovisa
Ann Geens
Vanessa A Morais
Georges Wagnières
Hubert van den Bergh
Alec Ginggen
Bart De Strooper
Yanik Tardy
Patrik Verstreken
Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
PLoS ONE
author_facet Melissa Vos
Blaise Lovisa
Ann Geens
Vanessa A Morais
Georges Wagnières
Hubert van den Bergh
Alec Ginggen
Bart De Strooper
Yanik Tardy
Patrik Verstreken
author_sort Melissa Vos
title Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
title_short Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
title_full Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
title_fullStr Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
title_full_unstemmed Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
title_sort near-infrared 808 nm light boosts complex iv-dependent respiration and rescues a parkinson-related pink1 model.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypothesis that 808 nm infrared light that effectively penetrates tissues rescues pink1 mutants. We show that irradiating isolated fly or mouse mitochondria with 808 nm light that is absorbed by ETC-Complex IV acutely improves Complex IV-dependent oxygen consumption and ATP production, a feature that is wavelength-specific. Irradiating Drosophila pink1 mutants using a single dose of 808 nm light results in a rescue of major systemic and mitochondrial defects. Time-course experiments indicate mitochondrial membrane potential defects are rescued prior to mitochondrial morphological defects, also in dopaminergic neurons, suggesting mitochondrial functional defects precede mitochondrial swelling. Thus, our data indicate that improvement of mitochondrial function using infrared light stimulation is a viable strategy to alleviate pink1-related defects.
url http://europepmc.org/articles/PMC3823844?pdf=render
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