A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme

A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme

Adventitious oxidation of erythrose-4-phosphate generates 4-phosphoerythronate, which is detoxified by metabolite-proofreading phosphatases in eukaryotes. Here, Sachla & Helmann show that a similar function is carried out in Bacillus subtilis by a checkpoint protein involved in ribosome assembly...

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Bibliographic Details
Main Authors: Ankita J. Sachla, John D. Helmann
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09508-z
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spelling doaj-6cfb84cfe69b4fd7bc8edc1f4efd293f2021-05-11T11:50:54ZengNature Publishing GroupNature Communications2041-17232019-04-0110111210.1038/s41467-019-09508-zA bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzymeAnkita J. Sachla0John D. Helmann1Department of Microbiology, Cornell UniversityDepartment of Microbiology, Cornell UniversityAdventitious oxidation of erythrose-4-phosphate generates 4-phosphoerythronate, which is detoxified by metabolite-proofreading phosphatases in eukaryotes. Here, Sachla & Helmann show that a similar function is carried out in Bacillus subtilis by a checkpoint protein involved in ribosome assembly.https://doi.org/10.1038/s41467-019-09508-z
collection DOAJ
language English
format Article
sources DOAJ
author Ankita J. Sachla
John D. Helmann
spellingShingle Ankita J. Sachla
John D. Helmann
A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
Nature Communications
author_facet Ankita J. Sachla
John D. Helmann
author_sort Ankita J. Sachla
title A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
title_short A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
title_full A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
title_fullStr A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
title_full_unstemmed A bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
title_sort bacterial checkpoint protein for ribosome assembly moonlights as an essential metabolite-proofreading enzyme
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description Adventitious oxidation of erythrose-4-phosphate generates 4-phosphoerythronate, which is detoxified by metabolite-proofreading phosphatases in eukaryotes. Here, Sachla & Helmann show that a similar function is carried out in Bacillus subtilis by a checkpoint protein involved in ribosome assembly.
url https://doi.org/10.1038/s41467-019-09508-z
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AT johndhelmann bacterialcheckpointproteinforribosomeassemblymoonlightsasanessentialmetaboliteproofreadingenzyme
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