Site-switchable mono-O-allylation of polyols

Selective manipulation of one functional group, out of many repeatedly occurring in a substrate, represents a grand challenge in chemistry. Here, the authors report a Pd/Lewis acid cocatalytic system that achieves not only site-selective, but also site-switchable mono-O-allylation of polyols.

Bibliographic Details
Main Authors: Hua Tang, Yu-Biao Tian, Hongyan Cui, Ren-Zhe Li, Xia Zhang, Dawen Niu
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19348-x