IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory re...

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Main Authors: Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15508
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spelling doaj-6cf86ce31a16462e8d6947a6f2906f202021-05-11T07:40:06ZengNature Publishing GroupNature Communications2041-17232017-05-018111610.1038/ncomms15508IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expressionChenhui Wang0Cun-Jin Zhang1Bradley N. Martin2Katarzyna Bulek3Zizhen Kang4Junjie Zhao5Guanglin Bian6Julie A. Carman7Ji Gao8Ashok Dongre9Haibo Xue10Stephen D. Miller11Youcun Qian12Dolores Hambardzumyan13Tom Hamilton14Richard M. Ransohoff15Xiaoxia Li16Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and TechnologyDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationDiscovery Biology, Bristol-Myers SquibbDiscovery Biology, Bristol-Myers SquibbDiscovery Biology, Bristol-Myers SquibbThe Department of Endocrinology and Metabolism, Binzhou Medical University HospitalDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern UniversityThe Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of MedicineDepartment of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory UniversityDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationBiogen IdecDepartment of Immunology, Lerner Research Institute, Cleveland Clinic FoundationNOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.https://doi.org/10.1038/ncomms15508
collection DOAJ
language English
format Article
sources DOAJ
author Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
spellingShingle Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
Nature Communications
author_facet Chenhui Wang
Cun-Jin Zhang
Bradley N. Martin
Katarzyna Bulek
Zizhen Kang
Junjie Zhao
Guanglin Bian
Julie A. Carman
Ji Gao
Ashok Dongre
Haibo Xue
Stephen D. Miller
Youcun Qian
Dolores Hambardzumyan
Tom Hamilton
Richard M. Ransohoff
Xiaoxia Li
author_sort Chenhui Wang
title IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_short IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_full IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_fullStr IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_full_unstemmed IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
title_sort il-17 induced notch1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to activate cell proliferation and an inflammatory response.
url https://doi.org/10.1038/ncomms15508
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