Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas

Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas

Temozolomide (TMZ) resistance is an important cause of clinical treatment failure and poor prognosis in gliomas. Increasing evidence indicates that cancer-derived exosomes contribute to chemoresistance; however, the specific contribution of glioma-derived exosomes remains unclear. The aim of this st...

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Bibliographic Details
Main Authors: Q.T. Wei, B.Y. Liu, H.Y. Ji, Y.F. Lan, W.H. Tang, J. Zhou, X.Y. Zhong, C.L. Lian, Q.Z. Huang, C.Y. Wang, Y.M. Xu, H.B. Guo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Oncolytics
Subjects:
glioma
temozolomide resistance
exosomes
MIF
TIMP3
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001157

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http://www.sciencedirect.com/science/article/pii/S2372770521001157

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