Current prodrug strategies for improving oral absorption of nucleoside analogues

Current prodrug strategies for improving oral absorption of nucleoside analogues

Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunodeficiency disease syndrome), cytomegalovirus infections, cancer, etc. However, many nucleoside analogues exhibit poor oral bioavailability because of their high polarity and low intestinal permeability...

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Bibliographic Details
Main Authors: Youxi Zhang, Yikun Gao, Xiaojing Wen, Haiying Ma
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Nucleoside analogues
Oral bioavailability
Prodrug
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087613000949

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