4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides

In a high-yielding and solvent-free procedure <i>N</i>-ethoxycarbonyl protected ω-amino-β-keto anilides undergo Knorr cyclisation in neat polyphosphoric acid to provide straightforward route to 4-aminoalkyl quinolin-2-one derivatives with variable length of the alkyl chain.

Bibliographic Details
Main Authors:	Plamen Angelov, Stilyana Velichkova, Pavel Yanev
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Molbank
Subjects:	Knorr quinolin-2-one 2-quinolone carbostyril solvent-free
Online Access:	https://www.mdpi.com/1422-8599/2021/3/M1266

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spelling	doaj-6ce8cfa2587242e9accb3dcbbff3ec312021-09-26T00:45:30ZengMDPI AGMolbank1422-85992021-08-012021M1266M126610.3390/M12664-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto AnilidesPlamen Angelov0Stilyana Velichkova1Pavel Yanev2Faculty of Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, BulgariaFaculty of Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, BulgariaFaculty of Chemistry, University of Plovdiv Paisii Hilendarski, 24 Tsar Asen Str., 4000 Plovdiv, BulgariaIn a high-yielding and solvent-free procedure <i>N</i>-ethoxycarbonyl protected ω-amino-β-keto anilides undergo Knorr cyclisation in neat polyphosphoric acid to provide straightforward route to 4-aminoalkyl quinolin-2-one derivatives with variable length of the alkyl chain.https://www.mdpi.com/1422-8599/2021/3/M1266Knorrquinolin-2-one2-quinolonecarbostyrilsolvent-free
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Plamen Angelov Stilyana Velichkova Pavel Yanev
spellingShingle	Plamen Angelov Stilyana Velichkova Pavel Yanev 4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides Molbank Knorr quinolin-2-one 2-quinolone carbostyril solvent-free
author_facet	Plamen Angelov Stilyana Velichkova Pavel Yanev
author_sort	Plamen Angelov
title	4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides
title_short	4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides
title_full	4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides
title_fullStr	4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides
title_full_unstemmed	4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides
title_sort	4-aminoalkyl quinolin-2-one derivatives via knorr cyclisation of ω-amino-β-keto anilides
publisher	MDPI AG
series	Molbank
issn	1422-8599
publishDate	2021-08-01
description	In a high-yielding and solvent-free procedure <i>N</i>-ethoxycarbonyl protected ω-amino-β-keto anilides undergo Knorr cyclisation in neat polyphosphoric acid to provide straightforward route to 4-aminoalkyl quinolin-2-one derivatives with variable length of the alkyl chain.
topic	Knorr quinolin-2-one 2-quinolone carbostyril solvent-free
url	https://www.mdpi.com/1422-8599/2021/3/M1266
work_keys_str_mv	AT plamenangelov 4aminoalkylquinolin2onederivativesviaknorrcyclisationofōaminobketoanilides AT stilyanavelichkova 4aminoalkylquinolin2onederivativesviaknorrcyclisationofōaminobketoanilides AT pavelyanev 4aminoalkylquinolin2onederivativesviaknorrcyclisationofōaminobketoanilides
_version_	1716869936838606848

4-Aminoalkyl Quinolin-2-one Derivatives via Knorr Cyclisation of ω-Amino-β-Keto Anilides

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