Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome

Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome

A positive direct antiglobulin test is a criterion for the diagnosis of systemic lupus erythematosus (SLE). In general, severe hemolysis is absent in SLE. Sometimes, these patients may show hemolysis when presenting with antiphospholipid syndrome (APS). It is essential to exclude an underlying alloa...

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Main Authors: Debasish Mishra, Girija Nandini Kanungo, Milind Agrawal, Aditi Khanna
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Iraqi Journal of Hematology
Subjects:
alloantibody
antibody screening
best-matched blood
blood grouping discrepancy
Online Access:http://www.ijhonline.org/article.asp?issn=2072-8069;year=2021;volume=10;issue=1;spage=84;epage=86;aulast=Mishra
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spelling doaj-6cd7b09933b748b1a7c4a0772e2b00af2021-07-07T13:14:47ZengWolters Kluwer Medknow PublicationsIraqi Journal of Hematology2072-80692021-01-01101848610.4103/ijh.ijh_8_21Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndromeDebasish MishraGirija Nandini KanungoMilind AgrawalAditi KhannaA positive direct antiglobulin test is a criterion for the diagnosis of systemic lupus erythematosus (SLE). In general, severe hemolysis is absent in SLE. Sometimes, these patients may show hemolysis when presenting with antiphospholipid syndrome (APS). It is essential to exclude an underlying alloantibody along with autoantibody. We had reported a case of a 24-year-old female SLE along with an APS patient requiring transfusion support with underlying allo-anti-S antibody. We provided two units of S antigen-negative best-matched units to the patient who tolerated it well and showed improvement.http://www.ijhonline.org/article.asp?issn=2072-8069;year=2021;volume=10;issue=1;spage=84;epage=86;aulast=Mishraalloantibodyantibody screeningbest-matched bloodblood grouping discrepancy
collection DOAJ
language English
format Article
sources DOAJ
author Debasish Mishra
Girija Nandini Kanungo
Milind Agrawal
Aditi Khanna
spellingShingle Debasish Mishra
Girija Nandini Kanungo
Milind Agrawal
Aditi Khanna
Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
Iraqi Journal of Hematology
alloantibody
antibody screening
best-matched blood
blood grouping discrepancy
author_facet Debasish Mishra
Girija Nandini Kanungo
Milind Agrawal
Aditi Khanna
author_sort Debasish Mishra
title Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
title_short Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
title_full Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
title_fullStr Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
title_full_unstemmed Transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
title_sort transfusion support in a severe autoimmune hemolytic anemia patient associated with systemic lupus erythematosus and antiphospholipid syndrome
publisher Wolters Kluwer Medknow Publications
series Iraqi Journal of Hematology
issn 2072-8069
publishDate 2021-01-01
description A positive direct antiglobulin test is a criterion for the diagnosis of systemic lupus erythematosus (SLE). In general, severe hemolysis is absent in SLE. Sometimes, these patients may show hemolysis when presenting with antiphospholipid syndrome (APS). It is essential to exclude an underlying alloantibody along with autoantibody. We had reported a case of a 24-year-old female SLE along with an APS patient requiring transfusion support with underlying allo-anti-S antibody. We provided two units of S antigen-negative best-matched units to the patient who tolerated it well and showed improvement.
topic alloantibody
antibody screening
best-matched blood
blood grouping discrepancy
url http://www.ijhonline.org/article.asp?issn=2072-8069;year=2021;volume=10;issue=1;spage=84;epage=86;aulast=Mishra
work_keys_str_mv AT debasishmishra transfusionsupportinasevereautoimmunehemolyticanemiapatientassociatedwithsystemiclupuserythematosusandantiphospholipidsyndrome
AT girijanandinikanungo transfusionsupportinasevereautoimmunehemolyticanemiapatientassociatedwithsystemiclupuserythematosusandantiphospholipidsyndrome
AT milindagrawal transfusionsupportinasevereautoimmunehemolyticanemiapatientassociatedwithsystemiclupuserythematosusandantiphospholipidsyndrome
AT aditikhanna transfusionsupportinasevereautoimmunehemolyticanemiapatientassociatedwithsystemiclupuserythematosusandantiphospholipidsyndrome
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