Association between Inflammation-Based Parameters and Prognosis in Patients with Acute Kidney Injury

• Main Authors: Hyelim Joo, Sun Young Min, Min-Su Park
• Format: Article
• Language: English
• Published: MDPI AG 2021-09-01
• Series: Medicina
• Subjects: acute kidney injury; inflammation; prognostic factor
• Online Access: https://www.mdpi.com/1648-9144/57/9/936

<i>Background and Objectives</i>: this study aimed to clarify the relationship between inflammation-based parameters and prognosis in patients with acute kidney injury (AKI). <i>Materials and Methods</i>: We analyzed the prospectively collected data of patients with AKI, who were admitted through the emergency department between March 2020 and April 2021. Their clinical characteristics, inflammation-based parameters, resolving/non-resolving AKI pattern, and major adverse kidney event (MAKE) rates were analyzed. <i>Results</i>: Among 177 patients, 129 (72.9%) had a resolving AKI pattern and 48 (27.1%) had a non-resolving AKI pattern. The outcome of MAKE occurred in 30 (16.9%) participants. Multivariate analyses showed that the neutrophil-to-monocyte ratio was an independent predictor of resolving AKI, and that the neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios were independent predictors of MAKE occurrence. <i>Conclusions</i>: we demonstrated that inflammation-based parameters are valuable predictors of early recovery and MAKE occurrence in patients with AKI.