Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed p...

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Main Authors:	Chang Xu, Wen-Hao Guo, Xu He, Yin-Long Guo, Xue-Ying Zhang, Xingang Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03532-1

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spelling	doaj-6cc8894e17964b75b809104e2d8eb40e2021-05-11T10:08:33ZengNature Publishing GroupNature Communications2041-17232018-03-019111010.1038/s41467-018-03532-1Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickelChang Xu0Wen-Hao Guo1Xu He2Yin-Long Guo3Xue-Ying Zhang4Xingang Zhang5Key Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of SciencesTransformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed pharmaceuticals.https://doi.org/10.1038/s41467-018-03532-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang
spellingShingle	Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel Nature Communications
author_facet	Chang Xu Wen-Hao Guo Xu He Yin-Long Guo Xue-Ying Zhang Xingang Zhang
author_sort	Chang Xu
title	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_short	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_full	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_fullStr	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_full_unstemmed	Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
title_sort	difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-03-01
description	Transformations with ClCF2H are very limited and normally involve a difluorocarbene intermediate. Here, the authors report a nickel-catalyzed difluoromethylation of aryl chlorides with chlorodifluoromethane via a difluoromethyl radical intermediate and apply the method to the synthesis of marketed pharmaceuticals.
url	https://doi.org/10.1038/s41467-018-03532-1
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Difluoromethylation of (hetero)aryl chlorides with chlorodifluoromethane catalyzed by nickel

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