Mechanism of Human Urotensin II-Induced Contraction in Rat Aorta

Mechanism of Human Urotensin II-Induced Contraction in Rat Aorta

Urotensin II induced sustained contraction with an EC50 value of 2.29 ± 0.12 nM in rat aorta. Urotensin II (100 nM) transiently increased cytosolic Ca2+ level ([Ca2+]i), followed by a small sustained phase superimposed with rhythmic oscillatory change. In the presence of verapamil and La3+, the [Ca2...

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Bibliographic Details
Main Authors: Katsunari Tasaki, Masatoshi Hori, Hiroshi Ozaki, Hideaki Karaki, Ichiro Wakabayashi
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319324727

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