Capturing the perfect pose
Lipid nanoparticles can be used to deliver nucleic acids for gene expression modulation—but getting them to target specific tissues is an ongoing challenge. In a new study by Dammes et al., a conformation-sensitive targeting strategy is used to achieve better selectivity in silencing gut-homing leuk...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02591-3 |
| Summary: | Lipid nanoparticles can be used to deliver nucleic acids for gene expression modulation—but getting them to target specific tissues is an ongoing challenge. In a new study by Dammes et al., a conformation-sensitive targeting strategy is used to achieve better selectivity in silencing gut-homing leukocytes in mouse models of colitis. |
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| ISSN: | 2399-3642 |