Update on the use of alitretinoin in treating chronic hand eczema

• Main Authors: Pedram Ghasri, Noah Scheinfeld
• Format: Article
• Language: English
• Published: Dove Medical Press 2010-04-01
• Series: Clinical, Cosmetic and Investigational Dermatology
• Online Access: http://www.dovepress.com/update-on-the-use-of-alitretinoin-in-treating-chronic-hand-eczema-a4266

Pedram Ghasri1, Noah Scheinfeld21University of California, Irvine School of Medicine, Irvine, CA, USA; 2Department of Dermatology, Columbia University, School of Medicine, New York, USAAbstract: Chronic hand eczema is a debilitating dermatological condition with significant economic, social, and functional impacts. To date, conventional treatments such as topical corticosteroids, phototherapy, and systemic immunosuppressants have yielded disappointing results, owing to either a lack of efficacy or significant adverse events. Oral alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid with immunomodulatory and anti-inflammatory activity that has emerged as a novel treatment for chronic hand eczema. Several large-scale clinical studies have demonstrated oral alitretinoin’s high efficacy rate of 28% to 89%, its safe tolerability profile, and its positive impact on quality of life, validating it as a therapeutic option for patients with severe chronic hand eczema refractory to standard treatment.Keywords: hand eczema, alitretinoin, 9-cisretinoic acid