Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1

Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1

Merkel cell polyomavirus (MCV) plays a causal role in ∼80% of Merkel cell carcinomas (MCC). MCV is clonally integrated into the MCC tumor genome, which results in persistent expression of large T (LT) and small T (sT) antigen oncoproteins encoded by the early locus. In MCV-positive MCC tumors, LT is...

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Bibliographic Details
Main Authors: Celestino Velásquez, Yutaka Amako, Alexis Harold, Tuna Toptan, Yuan Chang, Masahiro Shuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
Merkel cell polyomavirus
MCV
Merkel cell carcinoma
MCC
cell line
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00713/full

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