Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

Objective The therapeutic benefits of poly(ADP-ribose) polymerase inhibitors highlight the need to evaluate BRCA1/2 defects in tubal/ovarian cancer (OC). We sought to determine the pattern and disease characteristics associated with tumor BRCA1/2 mutations and BRCA1 methylation in women with OC. Met...

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Bibliographic Details
Main Authors: Roshni D. Kalachand, Ciaran O’Riain, Sinead Toomey, Aoife Carr, Kirsten M. Timms, Sharon O’Toole, Stephen Madden, Mark Bates, John J. O’Leary, Noreen Gleeson, Dearbhaile O’Donnell, Liam Grogan, Oscar Breathnach, Angela Farrelly, Britta Stordal, Bryan T. Hennessy
Format: Article
Language:English
Published: Korean Society of Obstetrics and Gynecology 2020-09-01
Series:Obstetrics & Gynecology Science
Subjects:
ovarian cancer
methylation
mutation
Online Access:http://www.ogscience.org/upload/pdf/ogs-20033.pdf

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