Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers

Poly(Aspartic Acid) Functionalized Poly(ϵ-Caprolactone) Microspheres with Enhanced Hydroxyapatite Affinity as Bone Targeting Antibiotic Carriers

Bone infection is a feared complication for patients with surgically fixed bone fractures and local antibiotic delivery is important in prophylaxis and treatment of these infections. Recent studies indicated that <i>Staphylococcus aureus</i> can penetrate bone tissue through micron-sized...

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Bibliographic Details
Main Authors: Stijn G. Rotman, Thomas F. Moriarty, Benjamin Nottelet, Dirk W. Grijpma, David Eglin, Olivier Guillaume
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
drug delivery
poly(aspartic acid)
bone infection
bone targeting
bone seeking agents
Online Access:https://www.mdpi.com/1999-4923/12/9/885

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