Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

Abstract The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergic neurones. Mounting evidence suggests that astrocytes may contribute to dopaminergic neurodegeneration through decreased homoeostatic support and deficient neuroprotection. In this study, we...

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Bibliographic Details
Main Authors: Paula Ramos-Gonzalez, Susana Mato, Juan Carlos Chara, Alexei Verkhratsky, Carlos Matute, Fabio Cavaliere
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-021-00175-w

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